NACSELD Acute-on-Chronic Liver Failure
NACSELD-ACLF (O'Leary 2018): a count of extrahepatic organ failures (circulatory, brain, renal, respiratory); ≥ 2 defines acute-on-chronic liver failure with sharply lower 30-day survival.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Circulatory failure
- Yes
- Brain failure
- No
- Renal failure
- Yes
- Respiratory failure
- No
Result: NACSELD-ACLF: 2 organ failure(s) — ACLF (>= 2), 30-day survival ~59%.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-1
- Not ACLF; 30-day survival ~93% at 0 failures.
- >= 2
- ACLF; 30-day survival ~59% (>= 2) to ~19% (4). Circulatory, brain, renal, respiratory failure. A prognostic count, not a treatment order.
What you enter
- Circulatory failure (shock)
- Brain failure (grade III–IV encephalopathy)
- Renal failure (dialysis)
- Respiratory failure (mechanical ventilation)
How this is calculated
O’Leary JG, Reddy KR, Garcia-Tsao G, et al. NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology. 2018;67(6):2367-2374. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.