WPSS (WHO Prognostic Scoring System for MDS)
WHO Prognostic Scoring System for MDS (Malcovati 2007): WHO morphologic category, karyotype, and transfusion dependence give a 0–6 score banding survival and leukemic progression.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- WHO category
- RAEB-1 (2)
- Karyotype
- Intermediate (1)
- Transfusion dependence
- Yes
Result: WPSS 4 — high risk (3-4).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-1
- Very low (0) / low (1) risk.
- 2
- Intermediate risk.
- 3-6
- High (3-4) / very high (5-6) risk. WHO category + karyotype + transfusion. A prognostic score, not a treatment order.
What you enter
- WHO category (0–3 points)
- Karyotype (good/intermediate/poor)
- Transfusion dependence (+1)
How this is calculated
Malcovati L, Germing U, Kuendgen A, et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol. 2007;25(23):3503-3510. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.