Wayne Index (Clinical Diagnosis of Thyrotoxicosis)
The Wayne index (Crooks, Murray and Wayne 1959) for the clinical diagnosis of thyrotoxicosis.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Symptom: Dyspnea on effort
- Yes
- Symptom: Palpitations
- Yes
- Symptom: Tiredness
- Yes
- Symptom: Temperature preference
- Prefers cold
- Symptom: Excessive sweating
- Yes
- Symptom: Nervousness
- Yes
- Symptom: Appetite
- Increased
- Symptom: Weight
- Decreased
- Sign: Palpable thyroid
- Yes
- Sign: Bruit over the thyroid
- Yes
The other 8 values
- Sign: Exophthalmos
- Yes
- Sign: Lid retraction
- Yes
- Sign: Lid lag
- Yes
- Sign: Hyperkinesis
- Yes
- Sign: Hands hot
- Yes
- Sign: Hands moist
- Yes
- Sign: Atrial fibrillation
- No
- Sign: Casual pulse rate
- Above 90/min
Result: Wayne index 41: toxic range.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Signed weights
- Several weights are negative: preferring heat -5, an absent palpable thyroid -3, absent hyperkinesis -2, a pulse below 80 -3. An exam with nothing found scores -10, not 0.
- Above 19
- Toxic range.
- 11 to 19
- Equivocal.
- Below 11
- Euthyroid.
- Not a lab test
- Published in 1959, before sensitive TSH assays. Not a substitute for TSH and free T4, and it does not identify the cause.
What you enter
- Symptom: Dyspnea on effort
- Symptom: Palpitations
- Symptom: Tiredness
- Symptom: Temperature preference
- Symptom: Excessive sweating
- Symptom: Nervousness
- Symptom: Appetite
- Symptom: Weight
- Sign: Palpable thyroid
- Sign: Bruit over the thyroid
The other 8 fields
- Symptom: Dyspnea on effort [no = No, 0; yes = Yes, +1]
- Symptom: Palpitations [no = No, 0; yes = Yes, +2]
- Symptom: Tiredness [no = No, 0; yes = Yes, +2]
- Symptom: Temperature preference [heat = Prefers heat, -5; neither = Neither, 0; cold = Prefers cold, +5]
- Symptom: Excessive sweating [no = No, 0; yes = Yes, +3]
- Symptom: Nervousness [no = No, 0; yes = Yes, +2]
- Symptom: Appetite [decreased = Decreased, -3; unchanged = Unchanged, 0; increased = Increased, +3]
- Symptom: Weight [increased = Increased, -3; unchanged = Unchanged, 0; decreased = Decreased, +3]
- Sign: Palpable thyroid [no = Absent, -3; yes = Present, +3]
- Sign: Bruit over the thyroid [no = Absent, -2; yes = Present, +2]
- Sign: Exophthalmos [no = Absent, 0; yes = Present, +2]
- Sign: Lid retraction [no = Absent, 0; yes = Present, +2]
- Sign: Lid lag [no = Absent, 0; yes = Present, +1]
- Sign: Hyperkinesis [no = Absent, -2; yes = Present, +4]
- Sign: Hands hot [no = Absent, -2; yes = Present, +2]
- Sign: Hands moist [no = Absent, -1; yes = Present, +1]
- Sign: Atrial fibrillation [no = Absent, 0; yes = Present, +4]
- Sign: Casual pulse rate [under80 = Below 80/min, -3; 80to90 = 80 to 90/min, 0; over90 = Above 90/min, +3]
How this is calculated
Crooks J, Murray IPC, Wayne EJ. Statistical methods applied to the clinical diagnosis of thyrotoxicosis. Q J Med. 1959;28(110):211-234. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.