TPMT and NUDT15 to Thiopurine Starting Dose (CPIC)
CPIC's starting-dose recommendation for mercaptopurine, azathioprine or thioguanine, from the TPMT and NUDT15 phenotypes.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Drug
- Azathioprine
- TPMT phenotype on the report
- Poor Metabolizer
- NUDT15 phenotype on the report
- Normal Metabolizer
Result: azathioprine, TPMT Poor Metabolizer, NUDT15 Normal Metabolizer: CPIC (Strong): "Consider alternative nonthiopurine immunosuppressant therapy."
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Drug
- TPMT phenotype on the report
- NUDT15 phenotype on the report
How this is calculated
Citation
CPIC TPMT, NUDT15 and Thiopurines guideline, read through the CPIC database (CC0 1.0): the combined TPMT and NUDT15 recommendation rows for mercaptopurine, azathioprine and thioguanine. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.