SPISE (Insulin Sensitivity Estimator)
SPISE (Paulmichl 2016) = 600 x HDL^0.185 / (TG^0.2 x BMI^1.338), lipids in mg/dL; a lower value reflects greater insulin resistance.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- HDL cholesterol
- 40 mg/dL
- Triglycerides
- 150 mg/dL
- BMI
- 30 kg/m^2
Result: SPISE 4.6 — suggests insulin resistance (< 5.4 in adolescents).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- >= 5.4
- Above the adolescent insulin-resistance cutoff.
- < 5.4
- Suggests insulin resistance / metabolic syndrome (600 x HDL^0.185 / (TG^0.2 x BMI^1.338); adult cutoffs differ). A surrogate index, not a diagnosis.
What you enter
- HDL cholesterol
- Triglycerides
- BMI
How this is calculated
Paulmichl K, Hatunic M, Hojlund K, et al. Modification and validation of the triglyceride-to-HDL cholesterol ratio as a surrogate of insulin sensitivity (SPISE). Clin Chem. 2016;62(9):1211-1219. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.