Matsuda Insulin Sensitivity Index (OGTT)
Matsuda insulin-sensitivity index from an OGTT: 10000 ÷ √(fasting glucose × fasting insulin × mean OGTT glucose × mean OGTT insulin).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Fasting glucose
- 110 mg/dL
- Fasting insulin
- 20 µU/mL
- Mean OGTT glucose
- 180 mg/dL
- Mean OGTT insulin
- 120 µU/mL
Result: Matsuda index 1.45 — suggests insulin resistance.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Interpretation
- Lower = more insulin resistant; below ~2.5 is commonly read as resistance (population-dependent).
What you enter
- Fasting glucose
- Fasting insulin
- Mean OGTT glucose
- Mean OGTT insulin
How this is calculated
- Formula
- ISI = 10000 / √(fasting glucose·fasting insulin·mean glucose·mean insulin), glucose mg/dL, insulin µU/mL.
Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22(9):1462-1470. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.