SLEDAI-2K (SLE Disease Activity Index 2000)
SLEDAI-2K SLE disease-activity index: 24 weighted descriptors (weights 8/4/2/1) present in the prior 10 days, total 0-105 (Gladman 2002).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Arthritis
- Yes
- Low complement
- Yes
- Increased DNA binding
- Yes
Result: SLEDAI-2K 8/105 — moderate activity (6–10) — ≥ 6 denotes clinically important active disease.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Descriptors
- 24 descriptors present in the prior 10 days, weighted 8/4/2/1, summed 0–105. SLEDAI-2K credits ongoing rash, alopecia, mucosal ulcers, and proteinuria.
- Activity
- ≥ 6 denotes clinically important active disease, a fall of ≥ 4 a meaningful improvement; 0 / 1–5 / 6–10 / 11–19 / ≥20 is a convention, not from the 2002 paper.
What you enter
- Seizure
- Psychosis
- Organic brain syndrome
- Visual disturbance
- Cranial-nerve disorder
- Lupus headache
- CVA
- Vasculitis
The other 16 fields
- Arthritis
- Myositis
- Urinary casts
- Hematuria
- Proteinuria
- Pyuria
- Rash
- Alopecia
- Mucosal ulcers
- Pleurisy
- Pericarditis
- Low complement
- Increased DNA binding
- Fever
- Thrombocytopenia
- Leukopenia
How this is calculated
Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288-291. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.