Simon Broome Criteria (Familial Hypercholesterolemia)
Simon Broome criteria for familial hypercholesterolemia: total cholesterol / LDL-C thresholds plus tendon xanthoma, DNA mutation, and family history of MI or hypercholesterolemia classify definite vs possible FH.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Total cholesterol
- 8.0 mmol/L
- LDL-C
- 0 mmol/L
- Child < 16 years
- No
- Tendon xanthoma
- Yes
- Causative DNA mutation
- No
- Family history of premature MI
- No
- Family history of raised cholesterol
- No
Result: Simon Broome: definite familial hypercholesterolemia.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Definite
- Cholesterol criterion plus tendon xanthoma or a causative DNA mutation.
- Possible
- Cholesterol criterion plus a family history of premature MI or raised cholesterol. A classification, not a statin order.
What you enter
- Total cholesterol
- LDL-C
- Child < 16 years (uses pediatric thresholds)
- Tendon xanthoma (patient or 1st/2nd-degree relative)
- Causative DNA mutation
- Family history of premature MI
- Family history of raised cholesterol
How this is calculated
Scientific Steering Committee on behalf of the Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolaemia. BMJ. 1991;303(6807):893-896. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.