Dutch Lipid Clinic Network Score (Familial Hypercholesterolemia)
Dutch Lipid Clinic Network score (WHO/Dutch criteria): family history, personal clinical history, physical exam, untreated LDL-C, and a causative DNA mutation give a score banding the probability of familial hypercholesterolemia.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Family history
- 1st-degree relative with premature CHD/vascular OR LDL > 95th pct (1)
- Personal clinical history
- Premature coronary heart disease (2)
- Physical examination
- Tendon xanthoma (6)
- Untreated LDL-C
- 7.0 mmol/L
- Causative DNA mutation
- No
Result: Dutch Lipid Clinic Network score 14 — definite familial hypercholesterolemia (> 8).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-2
- Familial hypercholesterolemia unlikely.
- 3-5
- Possible FH.
- 6-8
- Probable FH.
- > 8
- Definite FH. A classification, not a statin order.
What you enter
- Family history (0/1/2 points)
- Personal clinical history (0/1/2 points)
- Physical examination (0/4/6 points)
- Untreated LDL-C
- Causative DNA mutation (LDLR/APOB/PCSK9)
How this is calculated
Nordestgaard BG, Chapman MJ, Humphries SE, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians. Eur Heart J. 2013;34(45):3478-3490. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.