RegiSCAR Score for DRESS
RegiSCAR DRESS validation score (Kardaun 2007): fever, nodes, eosinophilia, atypical lymphocytes, skin extent/suggestiveness/biopsy, organ involvement, resolution, and cause exclusion → no case / possible / probable / definite.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Fever ≥ 38.5 °C
- Yes
- Enlarged lymph nodes
- Yes
- Eosinophilia band
- 700–1,499/µL or 10–19.9% (+1)
- Atypical lymphocytes
- Yes
- Skin involvement > 50% BSA
- No
- Rash suggestive of DRESS
- Unknown (0)
- Biopsy result
- Compatible / unknown (0)
- Organ involvement
- 1 organ (+1)
- Resolution ≥ 15 days
- No
- Other causes excluded
- No
Result: RegiSCAR 5 -- Probable DRESS (< 2 no case, 2-3 possible, 4-5 probable, > 5 definite). Contributions: fever >= 38.5C +1, lymph nodes +1, eosinophilia +1, atypical lymphocytes +1, organ involvement +1.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- < 2
- No case (DRESS excluded).
- 2-3
- Possible DRESS.
- 4-5
- Probable DRESS.
- > 5
- Definite DRESS.
What you enter
- Fever ≥ 38.5 °C
- Enlarged lymph nodes (≥ 2 sites)
- Eosinophilia band
- Atypical lymphocytes
- Skin involvement > 50% BSA
- Rash suggestive of DRESS
- Biopsy result
- Organ involvement
- Resolution ≥ 15 days
- Other causes excluded (≥ 3 negative tests)
How this is calculated
Kardaun SH, Sekula P, Valeyrie-Allanore L, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study. Br J Dermatol. 2013;169(5):1071-1080. Weighted -4 to +9. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.