Methadone Starting Dose From Another Opioid (FDA Label)
The estimated starting oral methadone dose from another oral opioid, by the FDA label's percentage table.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Coming from
- From another oral opioid (morphine equivalents)
- Total daily oral morphine-equivalent dose
- 100 mg
- Methadone doses a day
- 2
- Tablet strength in mg
- 5 mg tablets
Result: 10% to 20%, which is 10 mg to 20 mg a day; in 2 doses, 5 mg to 10 mg each
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Coming from: another oral opioid, or parenteral methadone
- Total daily oral morphine-equivalent dose (from another oral opioid)
- Methadone doses a day (from another oral opioid)
- Tablet strength in mg (from another oral opioid)
- Parenteral methadone dose over 24 hours (from parenteral methadone)
How this is calculated
Citation
FDA label on DailyMed: methadone hydrochloride tablets (Hikma), section 2.4, Table 1 (conversion factors to methadone as a percent of the total daily morphine equivalent dose; one way only) and the 1:2 parenteral to oral ratio. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.