Maddrey DF and Lille Model (alcoholic hepatitis)
Maddrey discriminant function (4.6 x (patient PT - control PT) + bilirubin; DF >= 32 severe alcoholic hepatitis) with the Lille model (day-0 vs day-7 response to steroids).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Patient prothrombin time
- 20 sec
- Control prothrombin time
- 12 sec
- Bilirubin
- 10 mg/dL
- Age
- 50 years
- Albumin
- 3.0 g/dL
- Creatinine
- 0.9 mg/dL
- Bilirubin day 0
- 10 mg/dL
- Bilirubin day 7
- 6 mg/dL
- Prothrombin time
- 20 sec
Result: Maddrey DF 46.8 - severe alcoholic hepatitis per Maddrey 1978 §Results; Lille model also computed.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- DF <32
- Not in the severe alcoholic hepatitis band per Maddrey 1978 §Results.
- DF >=32
- Severe alcoholic hepatitis per Maddrey 1978 §Results; corticosteroid therapy commonly considered.
- Lille <0.45
- Predicts response to steroids (6-month survival ~85% per Louvet 2007).
- Lille >=0.45
- Predicts non-response to steroids (6-month survival ~25% per Louvet 2007).
What you enter
- Patient prothrombin time
- Control prothrombin time
- Bilirubin (Maddrey)
- Age (Lille)
- Albumin (Lille)
- Creatinine (Lille)
- Bilirubin day 0 (Lille)
- Bilirubin day 7 (Lille)
- Prothrombin time (Lille)
How this is calculated
Maddrey WC, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978;75(2):193-199. Lille model: Louvet A, et al. Hepatology. 2007;45(6):1348-1354. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.