Generator Breakthrough Check: Mo-99, Sr-82 and Sr-85 (10 CFR 35.204)
Generator eluate breakthrough against the NRC limits and the generator label.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Generator
- Mo-99/Tc-99m generator (Technelite label)
- Technetium generator: Mo-99 at elution
- 100 µCi
- Technetium generator: Tc-99m at elution
- 1000 mCi
Result: Mo-99 breakthrough 0.1 µCi/mCi at elution is within the 0.15 limit; it stays within it for 3.87 hours after elution.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Generator
- Technetium generator: Mo-99 at elution
- Technetium generator: Tc-99m at elution
- Technetium generator: hours from elution to administration (optional)
- Technetium generator: aluminum in the eluate (optional)
- Rubidium generator: Sr-82 per mCi Rb-82
- Rubidium generator: Sr-85 per mCi Rb-82
- Rubidium generator: cumulative eluate volume (optional)
- Rubidium generator: days since calibration (optional)
How this is calculated
Citation
10 CFR 35.204(a) and 35.3204: 0.15 microcurie Mo-99 per millicurie Tc-99m; 0.02 and 0.2 microcurie Sr-82 and Sr-85 per millicurie Rb-82; reports at 7 and 30 calendar days. Technelite and Cardiogen-82 labels (DailyMed) for the label limits. Read the sources: 10 CFR 35.204 ↗, 10 CFR 35.3204 ↗, Technelite label ↗, Cardiogen-82 label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.