Gell and Coombs Hypersensitivity Classification
The Gell and Coombs classification of hypersensitivity reactions, the classic grouping by immune mechanism, types I/II/III/IV.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Gell and Coombs hypersensitivity type
- I - immediate, IgE-mediated (anaphylaxis, atopy)
Result: Gell and Coombs type I: immediate, IgE-mediated (anaphylaxis, atopy, urticaria).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Type I
- Immediate, IgE-mediated (anaphylaxis, atopy, urticaria).
- Type II
- Antibody-mediated cytotoxic, IgG/IgM (autoimmune hemolytic anemia, Goodpasture).
- Type III
- Immune-complex-mediated (serum sickness, SLE, Arthus reaction).
- Type IV
- Delayed, cell-mediated / T-cell (contact dermatitis, tuberculin reaction).
What you enter
- Gell and Coombs hypersensitivity type
How this is calculated
Rajan TV. The Gell-Coombs classification of hypersensitivity reactions: a re-interpretation. Trends Immunol. 2003;24(7):376-379. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.