Five-Factor Score 1996 (Systemic Necrotizing Vasculitis)
The ORIGINAL 1996 FIVE-FACTOR SCORE (Guillevin and colleagues) for systemic necrotizing vasculitis, one point per factor, 0 to 5, read as 0 / 1 / 2-or-more.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Proteinuria above 1 g per 24 hours
- Yes
- Serum creatinine above 140 micromol/L
- No
- Gastrointestinal involvement
- Yes
- Cardiomyopathy
- No
- Central nervous system involvement
- No
Result: 2
The tool opens with these values already filled in. Replace them with your own.
What the result means
- FFS 0
- No factor present.
- FFS 1
- One factor present.
- FFS 2 or more
- Two or more factors present.
- vs 2011
- Same name, same 0-5 range, same bands - and ONLY ONE shared factor (GI). An identical number does NOT mean the same thing.
- Dropped
- CNS involvement and proteinuria were DROPPED by the revision. Age over 65 and the ABSENCE of ENT manifestations were ADDED.
- Renal window
- This score needs creatinine ABOVE 140 umol/L; the revision needs 150 or more. A patient at 145 scores here and NOT there.
- Cohort
- Derived in PAN and Churg-Strauss. GPA (Wegener) entered only with the revision.
- Mortality
- DELIBERATELY WITHHELD - always null. The quoted percentages belong to the 2011 cohort and the 1996 figures could not be double-confirmed.
- Scope
- Group-level prognosis. Does not diagnose or classify a vasculitis, does not measure activity, does not select immunosuppression.
What you enter
- Proteinuria above 1 g per 24 hours.
- Serum creatinine above 140 micromol/L (1.58 mg/dL).
- Gastrointestinal involvement (hemorrhage, infarction or pancreatitis).
- Cardiomyopathy.
- Central nervous system involvement.
- Optional serum creatinine.
- Optional.
Full field descriptions
- Proteinuria above 1 g per 24 hours. In the 2011 revision: DROPPED from the 2011 revision entirely.
- Serum creatinine above 140 micromol/L (1.58 mg/dL). In the 2011 revision: Survived, but the threshold MOVED to at or above 150 micromol/L.
- Gastrointestinal involvement (hemorrhage, infarction or pancreatitis). In the 2011 revision: THE ONLY FACTOR THAT SURVIVED UNCHANGED.
- Cardiomyopathy. In the 2011 revision: Survived in altered form, as cardiac insufficiency.
- Central nervous system involvement. In the 2011 revision: DROPPED from the 2011 revision.
- Optional serum creatinine. Used only to detect the 10 micromol/L window in which this score and the revision disagree on the renal factor.
- Optional. Selecting granulomatosis-with-polyangiitis sets `outsideDerivationCohort`, because granulomatosis with polyangiitis was added only in the 2011 revision.
How this is calculated
- Factors
- Proteinuria over 1 g/24h; creatinine over 140 umol/L (1.58 mg/dL); GI involvement; cardiomyopathy; CNS involvement. One point each.
Guillevin L, Lhote F, Gayraud M, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore). 1996;75(1):17-28. Item comparison from Guillevin L, Pagnoux C, Seror R, et al. Medicine (Baltimore). 2011;90(1):19-27. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.