2022 ACR/EULAR Granulomatosis with Polyangiitis Classification Criteria
2022 ACR/EULAR granulomatosis-with-polyangiitis classification; a cumulative score ≥ 5 classifies as GPA, applied only after a small/medium-vessel-vasculitis diagnosis with mimics excluded.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Nasal involvement — bloody discharge
- Yes
- Positive cANCA or anti-PR3 antibody
- Yes
Result: 2022 ACR/EULAR 8/17 — ≥ 5: classify as granulomatosis with polyangiitis.
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What the result means
- Threshold
- a cumulative score ≥ 5 classifies as granulomatosis with polyangiitis (sensitivity 93%, specificity 94%).
What you enter
- Nasal involvement — bloody discharge, ulcers, crusting, congestion, blockage, or septal defect/perforation (+3)
- Cartilaginous involvement — ear/nose cartilage, hoarse voice/stridor, endobronchial, or saddle nose (+2)
- Conductive or sensorineural hearing loss (+1)
- Positive cANCA or anti-PR3 antibody (+5)
- Pulmonary nodules, mass, or cavitation on chest imaging (+2)
- Granuloma, extravascular granulomatous inflammation, or giant cells on biopsy (+2)
- Nasal/paranasal sinus inflammation, consolidation, or effusion, or mastoiditis on imaging (+1)
- Pauci-immune glomerulonephritis on biopsy (+1)
The other 2 fields
- Positive pANCA or anti-MPO antibody (-1)
- Blood eosinophil count ≥ 1 x10^9/L (-4)
How this is calculated
- Items
- 10 items summed, range -5 to +17: cANCA/PR3 +5; nasal +3; +2 each for cartilage, pulmonary nodules, granuloma; +1 each for hearing loss, sinus, pauci-immune GN; pANCA/MPO -1; eosinophils ≥ 1 -4.
Robson JC, Grayson PC, Ponte C, et al. 2022 American College of Rheumatology/EULAR classification criteria for granulomatosis with polyangiitis. Arthritis Rheumatol. 2022;74(3):393-399. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.