CYP Recovery Time After Induction or Inactivation (ICH M12)
Time for a CYP enzyme to return toward baseline after an inducer or irreversible inhibitor is stopped.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Enzyme for Table 6 kdeg
- CYP3A4 (hepatic)
- Starting level, fraction of baseline
- 3
- Hours since stopping
- 72
Result: 150.2% of baseline at 72 h
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Enzyme for Table 6 kdeg
- kdeg (per minute)
- Starting level, fraction of baseline
- Hours since stopping
- Washout delay (hours)
How this is calculated
Citation
ICH M12 Guideline, Drug Interaction Studies (Step 4, May 21, 2024), Table 6: representative turnover (kdeg and half-life) of major CYP enzymes; first-order return to baseline. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.