Dofetilide Starting Dose and QT Steps (Tikosyn Label)
The dofetilide initiation steps on the Tikosyn label.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Baseline QTc
- 420 msec
- Ventricular conduction abnormality
- No
- Creatinine clearance
- 60 mL/min
Result: Step 3: the label's starting dose is 250 mcg twice daily.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Baseline QTc (QT if heart rate under 60)
- Ventricular conduction abnormality
- Creatinine clearance (actual weight)
- QTc or QT 2 to 3 h after dose 1 (optional)
- QTc or QT after a later dose (optional)
How this is calculated
Citation
FDA label on DailyMed, Tikosyn (dofetilide), Dosage and Administration, Instructions for Individualized Dose Initiation, steps 1 to 6: QT limits, starting dose by creatinine clearance, the step-down after the first dose and the discontinuation rule. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.