DOAC Hold Before a Procedure (Labels and PAUSE)
The last DOAC dose before a procedure and the first after, by the label and by the PAUSE protocol.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- DOAC
- Apixaban (Eliquis)
- Adult or pediatric
- Adult
- Bleeding risk of the procedure
- High bleeding risk
- Source: both, label or pause
- PAUSE protocol only
- Procedure date and time
- 2026-10-15T08:00
- Creatinine clearance
- 80 mL/min
Result: last dose on Monday 2026-10-12
The tool opens with these values already filled in. Replace them with your own.
What you enter
- DOAC
- Adult or pediatric
- Bleeding risk of the procedure (your classification)
- Source: both, label or pause
- Procedure date and time (YYYY-MM-DDTHH:MM)
- Creatinine clearance (dabigatran, and any drug under PAUSE; pediatric dabigatran: eGFR)
How this is calculated
Citation
FDA labels on DailyMed: Eliquis 2.4, Xarelto 2.4, Pradaxa 2.8 and Savaysa 2.5 (discontinuation for surgery and other interventions). Douketis JD, et al. Perioperative management of patients with atrial fibrillation receiving a DOAC (PAUSE). JAMA Intern Med 2019;179(11):1469-1478. Read the sources: Eliquis label ↗, Xarelto label ↗, Pradaxa label ↗, Savaysa label ↗, Douketis 2019 (PAUSE) ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.