CYP3A4 Interaction Size From Contribution and Inhibition Ratios (Ohno)
CYP3A4 interaction size from the substrate's contribution ratio and the inhibitor's inhibition ratio (Ohno).
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- What to compute
- Predict an inhibition (CR and IR)
- CR
- 0.92
- IR
- 0.92
- Inhibitor dose the IR applies to
- itraconazole 200 mg
Result: Predicted AUC ratio 6.51.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- What to compute
- CR (0 to 1)
- IR (0 to 1)
- IC, increase in clearance
- Observed AUC ratio
- Inhibitor dose the IR applies to
How this is calculated
Citation
Ohno Y, et al. Clin Pharmacokinet 2007;46:681-696 and 2008;47:669 (the authors' abstracts: 1/(1 - CR x IR) and 1/(1 + CR x IC)); Tod M, et al. AAPS J 2014, Eq. 1 to 3 (back-calculation). Read the sources: Ohno 2007 ↗, Ohno 2008 ↗, Tod 2014 ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.