Corrected Sodium for Hyperglycemia
Corrected Sodium for Hyperglycemia - a deterministic tool in Sophie Well's Clinical Math & Conversions group.
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What this is
Compute glucose-corrected serum sodium using both of the published correction factors so the clinician can see them side by side. The classic Katz factor adds 1.6 mEq/L of sodium for every 100 mg/dL of glucose above 100; the Hillier factor (often called the 'true' correction, derived from a 1999 hyperglycemic-clamp study) adds 2.4 mEq/L per 100 mg/dL. Sophie Well takes the measured sodium and glucose and returns both corrected values along with the magnitude of the difference between them.
When to use it
Use this on any patient with hyperglycemia (DKA, hyperosmolar hyperglycemic state, severe hyperglycemia of any cause) where the measured sodium may be falsely low because glucose is osmotically drawing water into the vascular space and diluting the sodium. The corrected value, not the measured value, is what guides fluid choice and rate of correction. The 1.6 and 2.4 factors disagree most in profound hyperglycemia (glucose above 400); both are widely cited and most institutions default to one or the other - check your local protocol before acting on a marginal call.
References
Katz MA. NEJM. 1973. Hillier TA, Abbott RD, Barrett EJ. Am J Med. 1999;106(4):399-403.
Worked example: Corrected Na 138 (1.6); 142 (2.4)
Sophie Well is a reference and educational tool. Not medical, legal, or financial advice. Does not replace clinician judgment, professional billing review, or legal counsel.