Brighton GBS Criteria (certainty level)
Brighton Collaboration GBS case definition (Sejvar 2011): a diagnostic-certainty level 1-4 from bilateral flaccid limb weakness, decreased/absent reflexes, a monophasic course, the absence of an alternative diagnosis,…
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Example
- Bilateral flaccid limb weakness
- Yes
- Decreased / absent deep-tendon reflexes
- Yes
- Monophasic course, nadir 12 h-28 d
- Yes
- No alternative diagnosis
- Yes
- CSF result
- Albuminocytologic dissociation (cells < 50/µL, elevated protein)
- Nerve-conduction studies consistent with GBS
- Yes
Result: Brighton Level 1: the highest diagnostic certainty -- all core features plus CSF albuminocytologic dissociation and consistent nerve-conduction studies.
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What the result means
- Core
- bilateral flaccid limb weakness, decreased/absent reflexes in weak limbs, a monophasic course (onset-to-nadir 12 h-28 d), and the absence of an alternative diagnosis.
- Levels
- Level 1 = core + CSF dissociation + consistent NCS; Level 2 = core + a supportive CSF or consistent NCS; Level 3 = core only (CSF/NCS not done); Level 4 = insufficient evidence.
What you enter
- Bilateral flaccid limb weakness
- Decreased / absent deep-tendon reflexes
- Monophasic course, nadir 12 h-28 d
- No alternative diagnosis
- CSF result
- Nerve-conduction studies consistent with GBS
How this is calculated
Sejvar JJ, Kohl KS, Gidudu J, et al. Guillain-Barre syndrome and Fisher syndrome: case definitions for immunization safety data. Vaccine. 2011;29(3):599-612. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.