Boston Criteria v2.0 (cerebral amyloid angiopathy)
Boston Criteria v2.0 (Charidimou 2022) for cerebral amyloid angiopathy.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age 50 or older
- Yes
- Compatible presentation
- Yes
- Strictly lobar hemorrhagic lesions
- 2 or more lobar hemorrhagic lesions
Result: Probable CAA: >= 2 strictly lobar hemorrhagic lesions, with a compatible presentation, age 50 or older, and no deep hemorrhagic lesion.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Probable CAA
- two or more strictly lobar hemorrhagic lesions (lobar ICH, microbleeds, or siderosis foci) or one lobar lesion plus one white-matter feature.
- Possible CAA
- one strictly lobar hemorrhagic lesion or one white-matter feature; all in-vivo categories need age 50+, a compatible presentation, and no deep lesion.
What you enter
- Pathological confirmation
- Age 50 or older
- Compatible presentation (lobar ICH / TFNE / cognitive)
- Strictly lobar hemorrhagic lesions
- White-matter feature (CSO-PVS > 20 or WMH multispot)
- Deep hemorrhagic lesion present (exclusion)
How this is calculated
Charidimou A, Boulouis G, Frosch MP, et al. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Lancet Neurol. 2022;21(8):714-725. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.