Yamaguchi Criteria (Adult-Onset Still Disease)
Yamaguchi criteria for Adult-Onset Still’s Disease: classify when ≥ 5 of 8 criteria are present including ≥ 2 of the 4 major, and no exclusion (infection, malignancy, or other rheumatic disease) is present.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- MAJOR: fever ≥ 39°C lasting ≥ 1 week
- Yes
- MAJOR: arthralgia lasting ≥ 2 weeks
- Yes
- MAJOR: typical salmon-pink macular/maculopapular rash during fever
- Yes
- MAJOR: leukocytosis ≥ 10,000/mm³ with ≥ 80% granulocytes
- Yes
- MINOR: sore throat
- Yes
Result: Meets Yamaguchi criteria: 5 criteria including 4 major; classify as adult-onset Still’s disease.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- MAJOR: fever ≥ 39°C lasting ≥ 1 week
- MAJOR: arthralgia lasting ≥ 2 weeks
- MAJOR: typical salmon-pink macular/maculopapular rash during fever
- MAJOR: leukocytosis ≥ 10,000/mm³ with ≥ 80% granulocytes
- MINOR: sore throat
- MINOR: lymphadenopathy and/or splenomegaly
- MINOR: liver dysfunction (elevated transaminases/LDH)
- MINOR: negative rheumatoid factor AND negative ANA
The other 3 fields
- EXCLUSION: infection (e.g. sepsis, infectious mononucleosis)
- EXCLUSION: malignancy (e.g. malignant lymphoma)
- EXCLUSION: other rheumatic disease (e.g. polyarteritis nodosa, rheumatoid vasculitis)
How this is calculated
- Criteria
- 4 major (fever ≥ 39°C ≥ 1 wk, arthralgia ≥ 2 wk, salmon rash, leukocytosis with ≥ 80% granulocytes) and 4 minor (sore throat, lymphadenopathy/splenomegaly, liver dysfunction, negative RF and ANA).
- Rule
- classify when ≥ 5 of the 8 are present INCLUDING ≥ 2 major, AND no exclusion (infection, malignancy, other rheumatic disease) is present. Sensitivity 96.2%, specificity 92.1%.
Yamaguchi M, Ohta A, Tsunematsu T, et al. Preliminary criteria for classification of adult Still’s disease. J Rheumatol. 1992;19(3):424-430. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.