SOS (Sophia Observation withdrawal Symptoms)
Sophia Observation withdrawal Symptoms scale (Ista 2009): fifteen binary symptoms observed over the prior 4-hour window; total 0-15, >= 4 indicates clinically relevant iatrogenic withdrawal.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Tachycardia
- 1
- Tachypnea
- 0
- Fever
- 0
- Sweating
- 1
- Agitation
- 1
- Anxiety
- 0
- Grimacing
- 0
- Sleeplessness
- 1
- Hallucinations
- 0
- Motor disturbance
- 0
The other 5 values
- Hypertonia
- 0
- Tremor
- 1
- Vomiting
- 0
- Diarrhea
- 0
- Inconsolable crying
- 1
Result: SOS 6 of 15: iatrogenic withdrawal present per Ista 2009 (>=4 indicates clinically relevant iatrogenic withdrawal).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-3
- No significant withdrawal.
- >=4
- Iatrogenic withdrawal present per Ista 2009 (derivation Youden-optimal cutoff).
What you enter
- Tachycardia (0-1)
- Tachypnea (0-1)
- Fever (0-1)
- Sweating (0-1)
- Agitation (0-1)
- Anxiety (0-1)
- Grimacing (0-1)
- Sleeplessness (0-1)
- Hallucinations (0-1)
- Motor disturbance (0-1)
The other 5 fields
- Hypertonia (0-1)
- Tremor (0-1)
- Vomiting (0-1)
- Diarrhea (0-1)
- Inconsolable crying (0-1)
How this is calculated
Ista E, van Dijk M, de Hoog M, Tibboel D, Duivenvoorden HJ. Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children. Intensive Care Med. 2009;35(6):1075-1081. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.