PLASMIC score (TTP / ADAMTS13 probability)
PLASMIC score (Bendapudi 2017): 0-7 pretest probability of severe ADAMTS13 deficiency (acquired TTP) — platelet < 30, hemolysis, no active cancer, no transplant, MCV < 90, INR < 1.5, creatinine < 2.0.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Platelet count
- 18 ×10⁹/L
- Hemolysis sign
- Yes
- Active cancer in the past year
- No
- Prior solid-organ or stem-cell transplant
- No
- MCV
- 85 fL
- INR
- 1.2
- Creatinine
- 2.4 mg/dL
Result: PLASMIC 6 of 7 -- high (~62-82%) probability of severe ADAMTS13 deficiency (0-4 low, 5 intermediate, 6-7 high).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0-4
- Low probability of severe ADAMTS13 deficiency (~0-4%).
- 5
- Intermediate probability (~5-24%); consider the assay and clinical context.
- 6-7
- High probability (~62-82%); empiric plasma exchange is often started pending the assay.
What you enter
- Platelet count
- Hemolysis sign (retic > 2.5%, undetectable haptoglobin, or indirect bilirubin > 2.0)
- Active cancer in the past year
- Prior solid-organ or stem-cell transplant
- MCV
- INR
- Creatinine
How this is calculated
Bendapudi PK, Hurwitz S, Fry A, et al. Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol. 2017;4(4):e157-e164. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.