Neostigmine Reversal Dose (Bloxiverz Label)
Neostigmine dose to reverse neuromuscular blockade, as the BLOXIVERZ label states it.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Weight
- 70 kg
- Train-of-four response
- First twitch relatively weak: not substantially above 10% of baseline
- Half-life class of the blocker
- Longer half-life blocker (for example vecuronium, pancuronium)
- Concentration
- 1 mg/mL
Result: Neostigmine 4.9 mg (0.07 mg/kg), 4.9 mL of 1 mg/mL: both the half-life and the twitch response point to the label's 0.07 mg/kg row.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Weight
- Train-of-four response
- Half-life class of the blocker
- Concentration
- Neostigmine already given (optional)
How this is calculated
Citation
FDA label on DailyMed: BLOXIVERZ (neostigmine methylsulfate), sections 2.2 (0.03 or 0.07 mg/kg by train-of-four response and half-life; maximum 0.07 mg/kg or 5 mg), 2.4 (anticholinergic) and 3 (0.5 and 1 mg/mL). Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.