HScore (reactive hemophagocytic syndrome)
HScore (Fardet 2014) for reactive hemophagocytic lymphohistiocytosis.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Known underlying immunosuppression
- No
- Temperature
- 40 degrees C
- Hepatomegaly / splenomegaly
- Hepatomegaly and splenomegaly
- Number of cytopenias
- 2 lineages
- Ferritin
- 4000 ng/mL
- Triglyceride
- 3 mmol/L
- Fibrinogen
- 2 g/L
- AST
- 100 U/L
- Hemophagocytosis on marrow aspirate
- Yes
Result: HScore 274: estimated HLH probability >99% (Fardet 2014).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Score
- Nine weighted items, max 337: immunosuppression, temperature, organomegaly, cytopenia lineages, ferritin, triglyceride, fibrinogen, AST, marrow hemophagocytosis.
- Cutoff
- HScore >= 169 best discriminates reactive HLH (sensitivity 93%, specificity 86%); probability is read from the published curve.
What you enter
- Known underlying immunosuppression
- Temperature
- Hepatomegaly / splenomegaly
- Number of cytopenias (lineages)
- Ferritin
- Triglyceride
- Fibrinogen
- AST
- Hemophagocytosis on marrow aspirate
How this is calculated
Fardet L, Galicier L, Lambotte O, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014;66(9):2613-2620. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.