GALAD Score (HCC serum-biomarker probability)
GALAD score (Johnson 2014) — a serum-biomarker model for the probability that a lesion is hepatocellular carcinoma, from Gender, Age, AFP-L3, AFP, and DCP (des-gamma-carboxy-prothrombin / PIVKA-II).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Sex
- Male
- Age
- 65 years
- AFP-L3
- 10 %
- AFP
- 100 ng/mL
- DCP / PIVKA-II
- 200 mAU/mL
Result: GALAD Z 5.58
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Cutoff
- Z = -0.63 is a common cutoff (~85% sensitivity / 90% specificity). Assay units: AFP ng/mL, DCP mAU/mL, AFP-L3 %.
- Use
- Estimates the probability a lesion is HCC and outperforms AFP alone. A probability, not a diagnosis or a biopsy/imaging order.
What you enter
- Sex
- Age
- AFP-L3
- AFP
- DCP / PIVKA-II
How this is calculated
- Formula
- Z = -10.08 + 0.09*age + 1.67*(male=1) + 2.34*log10(AFP) + 0.04*AFP-L3 + 1.33*log10(DCP); probability = e^Z/(1+e^Z).
Johnson PJ, Pirrie SJ, Cox TF, et al. The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers. Cancer Epidemiol Biomarkers Prev. 2014;23(1):144-153. Z from gender, age, AFP-L3, AFP, DCP; cutoff Z = -0.63. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.