Neonatal Early-Onset Sepsis Calculator (Kaiser)
Kaiser Early-Onset Sepsis calculator (Kuzniewicz 2017): the probabilistic EOS risk per 1,000 live births from gestational age, maximum temperature, ROM duration, GBS status, intrapartum antibiotics, and the newborn exam.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Gestational age
- 39
- Maximum maternal temperature
- 100.4
- Duration of ROM
- 18
- Maternal GBS status
- Positive
- Intrapartum antibiotics
- None, or any antibiotic under 2 h before delivery
- Newborn clinical exam
- Well-appearing
Result: EOS risk 0.62 per 1,000 (risk at birth 1.50 per 1,000): below the 1 per 1,000 culture threshold, but the risk at birth is 1 per 1,000 or higher -- enhanced observation with vitals every 4 h for 24 h.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Prior
- a logistic model over gestational age, highest intrapartum temperature (°F), ROM duration, GBS status, and intrapartum antibiotics gives the EOS risk at birth.
- Posterior
- the prior is combined by Bayes with the exam likelihood ratio (well 0.41, equivocal 5.0, clinical illness 21.2) to give the EOS probability per 1,000.
- Management
- under 1/1,000 routine care; 1 to under 3 blood culture; 3 or more empiric antibiotics; enhanced observation when risk at birth is 1/1,000 or higher.
What you enter
- EOS baseline incidence (per 1,000)
- Gestational age (weeks)
- Maximum maternal temperature (°F)
- Duration of ROM (hours)
- Maternal GBS status
- Intrapartum antibiotics
- Newborn clinical exam
How this is calculated
Kuzniewicz MW, Puopolo KM, Fischer A, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 2017;171(4):365-371; on the model of Puopolo KM, et al. Pediatrics. 2011;128(5):e1155. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.