Disproportionality From a 2×2 of Report Counts (ROR, PRR, IC)
Reporting odds ratio, proportional reporting ratio and information component from four report counts.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- a: reports with the drug and the event
- 15
- b: reports with the drug and other events
- 100
- c: reports with other drugs and the event
- 5000
- d: reports with other drugs and other events
- 100000
Result: ROR 3 (95% interval 1.74 to 5.17); PRR 2.74; IC 1.37 (IC025 0.5, IC975 1.97).
The tool opens with these values already filled in. Replace them with your own.
What you enter
- a: reports with the drug and the event
- b: reports with the drug and other events
- c: reports with other drugs and the event
- d: reports with other drugs and other events
- EU additional monitoring list (optional)
- Event on the Important Medical Event list (optional)
How this is calculated
Citation
European Medicines Agency. Screening for adverse reactions in EudraVigilance (EMA/849944/2016), section 4.1.3 and annex (ROR). Noren GN, Hopstadius J, Bate A. Stat Methods Med Res 2013;22(1):57-69 (information component and limits). Read the sources: EMA/849944/2016 ↗, Noren 2013 ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.