Cryptococcal Antigen Screening and Fluconazole in Advanced HIV (WHO)
Says whether to screen for cryptococcal antigen before ART and what to give: screening below CD4 100 (consider below 200), never under 10, and pre-emptive fluconazole doses for adults or per kg for adolescents.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Age in years
- 16
- CD4 count, cells/mm³
- 80
- Cryptococcal antigen result
- Positive
- Signs or symptoms of meningitis
- No
- Weight in kg
- 45
Result: Positive, no signs of meningitis: do a lumbar puncture where feasible to exclude meningitis, then give pre-emptive fluconazole (adolescent doses below).
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Age in years
- CD4 count, cells/mm³
- Cryptococcal antigen result
- Signs or symptoms of meningitis
- Weight in kg (adolescents 10-19)
How this is calculated
Citation
WHO. Guidelines on the management of advanced HIV disease. December 2025, Table 2. WHO. Guidelines for diagnosing, preventing and managing cryptococcal disease. 2022, section 2.2 (pp. 5-7) and the consolidation and maintenance doses. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.