Albumin-corrected phenytoin (Sheiner-Tozer)
Albumin-corrected total phenytoin (Sheiner-Tozer) = measured/(0.2*albumin + 0.1); ESRD uses 0.1 factor.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Measured total phenytoin
- 8 ug/mL
- Serum albumin
- 2.0 g/dL
Result: Corrected phenytoin 16 ug/mL — within the 10-20 ug/mL therapeutic range.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Measured total phenytoin
- Serum albumin
How this is calculated
Winter ME, Tozer TN. Phenytoin. In: Applied Pharmacokinetics, 3rd ed. 1992 (Sheiner-Tozer correction). Corrected = measured / (0.2 x albumin + 0.1); 0.1 factor for CrCl<10/ESRD. Therapeutic total 10-20 ug/mL.
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.