Albumin-corrected phenytoin (Sheiner-Tozer)
Total phenytoin corrected for a low albumin (Sheiner-Tozer).
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Measured total phenytoin
- 8 ug/mL
- Serum albumin
- 2.0 g/dL
Result: Corrected phenytoin 16 ug/mL — within the 10-20 ug/mL therapeutic range.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Measured total phenytoin
- Serum albumin
- CrCl <10 mL/min or ESRD (0.1 factor)
- Albumin coefficient (default 0.2)
How this is calculated
Citation
Winter ME, Tozer TN. Phenytoin. In: Applied Pharmacokinetics, 3rd ed. 1992 (Sheiner-Tozer correction, coefficient 0.2; 0.1 for CrCl<10/ESRD). Cheng W, et al. Can J Hosp Pharm 2016;69:269-279 (0.275). Dilantin label on DailyMed: total 10-20, unbound 1-2 mcg/mL. Read the sources: Cheng 2016 ↗, Dilantin label ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.