Congenital Syphilis Evaluation Scenario (CDC 2021)
CDC 2021 congenital syphilis scenario, evaluation, and penicillin dose for a newborn whose mother has reactive syphilis serology.
Open the tool → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Infant physical exam
- Normal
- Darkfield or PCR positive
- No
- Infant nontreponemal titer, the number after 1
- 4
- Maternal nontreponemal titer at delivery, the number after 1
- 16
- Maternal treatment
- Penicillin, appropriate for stage, during pregnancy
- Date maternal treatment began
- 2026-08-07
- Delivery date
- 2026-09-01
- Maternal evidence of reinfection or relapse
- No
- Infant weight
- 3.2
Result: Treatment began 25 days before delivery, under the 30-day cut, so this is Scenario 2: possible congenital syphilis.
The tool opens with these values already filled in. Replace them with your own.
What you enter
- Infant physical exam
- Darkfield or PCR positive
- Infant nontreponemal titer, the number after 1: (0 if nonreactive)
- Maternal nontreponemal titer at delivery, the number after 1:
- Maternal treatment
- Date maternal treatment began (YYYY-MM-DD)
- Delivery date (YYYY-MM-DD)
- Maternal evidence of reinfection or relapse
- Maternal titer low and stable, if treated before pregnancy
- Infant weight (kg)
How this is calculated
Workowski KA, Bachmann LH, Chan PA, et al. Sexually Transmitted Infections Treatment Guidelines, 2021 (CDC), Congenital Syphilis. MMWR Recomm Rep. 2021;70(4):1-187. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.