CLIP Score (Cancer of the Liver Italian Program)
CLIP score for hepatocellular carcinoma (CLIP Investigators 1998): Child-Pugh stage, tumor morphology, AFP, and portal-vein thrombosis sum to 0–6, with median survival falling from ~36 months at 0 to ~3 months at 4–6.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Child-Pugh stage
- B (+1)
- Tumor morphology
- Multinodular and ≤ 50% liver (+1)
- Alpha-fetoprotein
- 500 ng/mL
- Portal-vein thrombosis
- Yes
Result: CLIP 4 — median survival ≈ 3 months in the prospective validation cohort.
The tool opens with these values already filled in. Replace them with your own.
What the result means
- Survival
- Median survival by score: 0 ≈ 36 mo, 1 ≈ 22, 2 ≈ 9, 3 ≈ 7, 4–6 ≈ 3. Integrates liver function with tumor burden and AFP, complementary to BCLC; a stratifier, not a treatment order.
What you enter
- Child-Pugh stage
- Tumor morphology
- Alpha-fetoprotein
- Portal-vein thrombosis (+1)
How this is calculated
- Items
- Child-Pugh A/B/C → 0/1/2; tumor morphology uninodular ≤ 50% / multinodular ≤ 50% / massive or > 50% → 0/1/2; AFP < 400 / ≥ 400 ng/mL → 0/1; portal-vein thrombosis no/yes → 0/1. Total 0–6.
The Cancer of the Liver Italian Program (CLIP) Investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology. 1998;28(3):751-755. Median survival by score from the prospective validation, Hepatology. 2000;31(4):840-845. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.