CISNE (stable febrile-neutropenia complication risk)
CISNE: 0-8 serious-complication score for clinically stable febrile-neutropenia outpatients — ECOG ≥ 2, stress hyperglycemia, COPD, cardiovascular disease, mucositis ≥ 2, monocytes < 200; 0 low, 1-2 intermediate, ≥ 3 high.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- ECOG performance status
- 2
- Stress-induced hyperglycemia
- No
- COPD
- Yes
- Chronic cardiovascular disease
- No
- NCI mucositis grade
- 0
- Monocyte count
- 300 /µL
Result: CISNE 3 of 8 -- high (~36%) risk of serious complications (0 low, 1-2 intermediate, >= 3 high).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- 0
- Low risk of serious complications (~1.1%).
- 1-2
- Intermediate risk (~6.2%).
- 3-8
- High risk (~36%); the stable-appearance reassurance does not apply.
What you enter
- ECOG performance status (0-4)
- Stress-induced hyperglycemia
- COPD
- Chronic cardiovascular disease
- NCI mucositis grade (0-4)
- Monocyte count
How this is calculated
Carmona-Bayonas A, et al. Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the CISNE in a prospective cohort from the FINITE study. J Clin Oncol. 2015;33(5):465-471. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.