Clinical Activity Score (Thyroid Eye Disease)
Clinical Activity Score (Mourits 1989; EUGOGO) for thyroid eye disease / Graves orbitopathy — a 7-item initial-assessment measure of disease activity.
Open the calculator → Runs in your browser. Data leaves only if you deliberately send a problem report from the interactive tool.
Example
- Spontaneous orbital (retrobulbar) pain
- Yes
- Gaze-evoked orbital pain
- Yes
- Eyelid swelling
- Yes
Result: Clinical Activity Score 3 of 7: active thyroid eye disease (CAS >= 3).
The tool opens with these values already filled in. Replace them with your own.
What the result means
- CAS 0-2
- Inactive by CAS: below the >= 3 activity threshold.
- CAS >= 3
- Active thyroid eye disease; the classically taught threshold for considering anti-inflammatory treatment.
What you enter
- Spontaneous orbital (retrobulbar) pain
- Gaze-evoked orbital pain
- Eyelid swelling (active TED)
- Eyelid erythema
- Conjunctival redness (active TED)
- Chemosis
- Inflammation of the caruncle or plica
How this is calculated
- Items
- One point each: spontaneous orbital pain, gaze-evoked pain, eyelid swelling, eyelid erythema, conjunctival redness, chemosis, caruncle/plica inflammation.
Mourits MP, Koornneef L, Wiersinga WM, et al. Clinical criteria for the assessment of disease activity in Graves ophthalmopathy: a novel approach. Br J Ophthalmol. 1989;73(8):639-644. Read the source ↗
A reference and educational tool. Not medical, legal, or financial advice, and not a substitute for clinician judgment.